ea0029oc17.3 | Diabetes Basic | ICEECE2012
Ojo O.
, Conlon J.
, Flatt P.
, Abdel-Wahab Y.
We reported the isolation and structural characterization of CPF-AM1 and other peptides from the skin secretion of Xenopus amieti. This study investigated the insulin-releasing activities of synthetic CPF-AM1 using clonal pancreatic cell line, BRIN-BD11 and Swiss TO mice with diet-induced insulin resistance.Acute insulin-release studies were performed in Krebs Ringer bicarbonate buffer supplemented with 5.6 mM or 16.7 mM glucose, purified synthetic pepti...